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Since the effects of NO are concentration dependent, cyclic guanosine monophosphate (cGMP) has been thought to mediate NO-associated signal transduction as a second messenger at low ( 140/90 mm Hg, taken on two separate occasions at least 6 hours apart along with proteinuria ( 0.3 g protein in a 24-hour urine specimen or persistent 1+ (30 mg/dL) protein on dipstick) after 20 weeks of gestation

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