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Vaccaro O, Masulli M, Nicolucci A et al (2017) Effects on the incidence of cardiovascular events of the addition of pioglitazone versus sulfonylureas in patients with type 2 diabetes inadequately controlled with metformin (TOSCA.IT): a randomised, multicentre trial

The receptor type 1 (TAS1R) aggregates as heteromers, with different combinations that recognize specific classes of tastes: TAS1R2 + TAS1R3 for sweet and TAS1R1 + TAS1R3 for umami