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Notably, ADF has demonstrated significant immunomodulatory properties through the suppression of NLRP3 inflammasome activation, resulting in attenuated secretion of downstream pro-inflammatory cytokines, particularly interleukin-1 (IL-1) and interleukin-18 (IL-18) (Wu et al

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Moreover, it is not known if S-5-HT mediated the effects of L-carnitine on fatigue, as it is possible that L-carnitine could have effects unrelated to S-5-HT that could reduce fatigue and in parallel promote increased synthesis of peripheral 5-HT