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This is an important discovery that identified the long-sought-after incretin (an intestine-secreted hormone that triggers insulin release) and led to its application as an anti-diabetic strategy

In fact, their HS flares occurred every 12 weeks while on semaglutide, compared to a flare every 8.5 weeks before starting the drug

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Studies have shown that significant concentrations of lixisenatide were found in the brain of mice 30 minutes and 3 hours after intraperitoneal injection, suggesting that lixisenatide could cross the BBB (125)