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00:04:03 Vickie Danaher For example, GLP-1 increases insulin secretion from the pancreas

If the individual taking Mounjaro does not experience any severe side effects from taking the 12.5 mg dose after weeks 17-20, they should switch to a higher dose of Mounjaro 15 mg to continue with their weight loss treatment

Risk of bias assessment To assess the quality of the included RCTs, we used the Cochrane Collaborations risk-of-bias tool (33), which provided an independent assessment of the risk of bias in the main outcomes of each trial

Clinical trial data from the SURMOUNT-1 study demonstrated that patients achieved maximum weight loss at approximately 72 weeks (18 months), with average reductions of 15.0% (5 mg), 19.5% (10 mg), and 20.9% (15 mg) of initial body weight