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The cytoprotective role of SFN is demonstrated by a study using A 2535 (25 M) cytotoxicity and its interaction with Nrf2 in SH-SY5Y cell lines (84)

Ribonucleotide reduction typically requires a metal cofactor and an oxidant in the R2 subunit (encoded by nrdF ) that ultimately oxidizes an active site cysteine side chain in the R1 subunit to create a thiyl radical

[DOI] [PubMed] [Google Scholar] 42.Peng F., Chen Y., Chen C.Y., Dormer P.G., Kassim A., McLaughlin M., Reamer R.A., Sherer E.C., Song Z.J., Tan L., et al

Carnosine exerts antitumor activity against bladder cancers in vitro and in vivo via suppression of angiogenesis