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This gradual titration helps minimize gastrointestinal side effects such as nausea, vomiting, and diarrhea, which are the most commonly reported adverse effects during the initial treatment phase

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Wegovy pens, on the other hand, each contain a single dose of Wegovy, and should be disposed of after one use

This guide breaks down every major difference between tirzepatide and semaglutide in 2026, drawing on the latest clinical trial data, real-world studies, and updated FDA guidance so you and your provider can make a genuinely informed decision