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This comprehensive mechanism addresses appetite, energy expenditure, gastric function, and glucose homeostasis through distinct but complementary receptor systems, potentially explaining enhanced efficacy observed in combination approaches compared to monotherapies

Efficacy in Diabetic Neuropathy: Systematic reviews demonstrate that ALC significantly reduces pain in diabetic peripheral neuropathy and enhances nerve conduction, suggesting its utility in nerve repair and pain relief (Veronese et al., 2017)

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