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The most common side effects of retatrutide are nausea, vomiting, diarrhea, abdominal discomfort, and constipation

Beginners often start on the lower end (around 100-200 mg) to assess tolerance, then may increase to higher doses (500+ mg) in later sessions

Taking extra doses increases side effects without improving weight loss outcomes

Sodium-glucose co-transporters are responsible for 97% of glucose reabsorption6 and their inhibition lowers blood glucose by increasing renal glucose excretion.4 , 5 Using SGLT-2 inhibitors increases the risk of DKA6 , 7 by decreasing daily carbohydrate availability by 20%45%,9 lowering endogenous insulin production and stimulating lipolysis that leads to ketogenesis.6 Patients who also receive insulin may decrease insulin doses in response to lower blood glucose patterns, leading to insulin deficiency