Should be taken with the first bite of breakfast, lunch, and dinner the hypoglycemic goal in diabetics typically cannot be met with these drugs alone Side Effects: bloating, gas, abdominal discomfort, diarrhea these side effects develop due to the fermenting of undigested carbohydrate in the colon to fatty acids, with resultant release of gas side effects can diminish over time due to upregulation of -glucosidase in the distal small intestine, which increases glucose absorption & reduces the amount of carbohydrate entering the colon Major drug interactions: ) MAO inhibitors Notes: -glucosidase inhibitors are infrequently prescribed in the US because of their prominent GI side effects & limited ability to lower glucose levels -glucosidases are a family of enzymes with different carbohydrate specificities, and include sucrase, maltase, glucoamylase & dextranase References: Masharani U, Kroon L (2024): Pancreatic Hormones & Antidiabetic Drugs (Chapter 41)
We could see companies like Insperity (NSP) take a serious hit on the popularity of GLP-1 drugs
For those who are unable to eat these foods are have trouble fitting these in with daily meals, supplementation can be provided in the form of B-12 injections
Some products employ enteric coating or liposomal formulations to improve GI absorption, but efficacy of these delivery strategies for AOD-9604 specifically has not been validated
