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Absolute concentration should therefore be interpreted alongside GSSG, total pool size, sample viability, and pathway context

A report has shown that KDM3B, a histone H3 lysine 9 demethylase, can protect against erastin-induced ferroptosis and is thus considered a potential epigenetic regulator of ferroptosis (Wang et al., 2020)

Mitochondria generate the majority of cellular ROS as a byproduct of oxidative phosphorylation, and mitochondrial GSH is the primary defense against this constant oxidative burden

Cell Rep 30(34113423):e3417 Festjens N, Berghe TV, Vandenabeele P (2006) Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response