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BRP: The Endogenous Hypothalamic Scalpel EVIDENCE TIER, PRECLINICAL / TRANSLATIONAL HYPOTHESIS In April 2026, a team at Stanford led by Katrin Svensson published in Nature a finding that, depending on how it translates to humans, may turn out to be one of the most significant peptide discoveries of the decade

Due to the breadth of this subject matter, we have limited this review focussing on triagonists, whereby some other promising gut hormone compounds, such as cagrilintide, reviewed elsewhere [10], are not discussed

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Phoenixin signals primarily through the G proteincoupled receptor GPR173, although aspects of its signaling biology remain incompletely defined