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The molecule was discovered and characterised at Novo Nordisk by Lotte Bjerre Knudsen and her team across the early 2010s, and the foundational publication is Lau et al., "Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide" (J

In contrast, asymptomatic patients without risk factors generally do not require pre-treatment screening