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doi: 10.1586/14787210.2015.1064309 [DOI] [PMC free article] [PubMed] [Google Scholar] 51.Piller T, De Vooght L, Gansemans Y, Van Nieuwerburgh F, Cos P

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Activation of GLP-1R by exendin-4 promoted the osteogenic differentiation, increased bone formation and osteoblast number and inhibited BMSC adipogenic differentiation, but wortmannin (PI3K inhibitor), and GLP-1R sh-RNA partially blocked the exendin-4-induced PI3K/AKT signaling activation and attenuated the facilitating effect of exendin-4 in BMSCs (Figure 1)

Specifically, researchers discovered that the L cells found in the ileum, the final and longest part of the small intestine, release two important gut peptides: GLP-1 and peptide tyrosine tyrosine (PYY), both of which contribute to satiety and the regulation of appetite and food intake