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How the medication works Tirzepatide engages the GIP and GLP-1 receptors in the pancreas, hypothalamus, and gastrointestinal tract slowing gastric emptying, blunting post-meal glucose excursions, reducing appetite, and increasing satiety signaling

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3.1.2.5 SIRT5 SIRT5 is a pivotal enzyme that promotes metabolic homeostasis, inhibiting mitochondrial fission and degradation processes, reducing the susceptibility of the mitochondria to oxidative stress-induced mitochondrial dysfunction