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Immunological factors play a prominent role in the development of this disease (204)

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Considerations for switching to semaglutide OW included, but were not limited to, a need to further reduce HbA1c (compared to the reduction achieved with dulaglutide and liraglutide), a desire for greater weight loss (compared to that achieved with dulaglutide and liraglutide), decreased frequency of administration (compared to liraglutide), cardiovascular protection (compared to dulaglutide, based on data available at the time the switch was conducted between March 2018 and June 2019), and the potential to reduce the doses of other concomitant diabetes medications, including insulin (compared to the doses of those medications when used with dulaglutide and liraglutide)

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