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Mutations in phospholipase DDHD2 cause autosomal recessive hereditary spastic paraplegia (SPG54)

Glutathione can directly neutralize ROS such as lipid peroxides, and also plays a major role in xenobiotic metabolism

Key Points The value of many promising drug candidates is diminished by the presence of barriers between blood and brain that possess both structural and enzymatic components at the level of the cerebral capillaries, the epithelia of the choroid plexuses and other circumventricular organs, and the arachnoid membranes