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the gradual reaction of the hydrogen or the electrons via a cascade of intermediate carriers gradually releases the high reaction enthalpy emitted during the formation of water from hydrogen and oxygen and stores a considerable proportion in the form of chemical energy as adenosine triphosphate (ATP) for energy-consuming cell reactions

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reported two novel groups of heterocyclic DPP-4 inhibitors (Figure 5), including pyrimidinones (compounds 33, 34) and pyrimidinediones (compound 35), which were identified as active DPP-4 inhibitors (89)

Any switch within this medication class after a suspected hypersensitivity reaction should involve careful clinician assessment