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These enzymes catalyze nucleophilic attack of reduced glutathione (GSH) on nonpolar compounds that contain an electrophilic carbon, nitrogen, or sulfur atom leading to formation of thioether conjugates

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Mice heterozygous for a disrupted UA oxidase transgene (UO X +/) exhibited diminished brain damage and enhanced functional recovery following ischemic stroke, prompted researchers to explore the potential role of UA treatment in animal stroke models [145]

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