It was reported that knockdown of NAD + kinase (NADK), an enzyme that uses NAD + to synthesize NADP(H), was able to decrease NADP(H) levels in HT1080 cells and make them more susceptible to ferroptosis inducers ( RAS mutant tumors ( KRAS mutant Calu-1 non-small cell lung cancer cells ( Thioredoxin, a member of cellular antioxidant family ( As mentioned above, in some cell types, cysteine can be generated through the transsulfuration pathway rather than system
Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation
J Biol Chem 281 , 15991604 (2006)
Foods rich in sulfur-containing amino acids, such as garlic, onions, and cruciferous vegetables (broccoli, cauliflower, kale, and Brussels sprouts), are particularly beneficial for boosting glutathione levels