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Nutrients absorbed in the intestine and microbial metabolites are collected via the superior and inferior mesenteric veins into the portal vein, entering the liver directly for first-pass metabolism. This unique circulatory pathway positions the liver as the first station for processing gut-derived substances ( The portal venous system carries multiple signaling molecules from the intestine

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At its core, IGF-1 LR3 is a polypeptide, a delicate chain of 83 amino acids folded into a precise three-dimensional shape