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J.WhiteC

In addition, EMPA impacted neuroprotective effects by alleviating the neuronal loss in the hippocampal region, the marked dysregulation of Npas4 and CREB contents, and the enhancement of neuronal survival and plasticity, as evidenced by the encouragement of sufficient proteolytic cleavage of the precursor (proBDNF) and the formation of the mature (mBDNF) that binds to its high-affinity receptor (TrkB) to play a role in neurogenesis and prevention against the deteriorating effects of PTZ

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The research adhered to the ethical principles outlined in the Declaration of Helsinki, with all participants providing informed consent 15