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The tradeoff is slightly less precision at the lowest titration doses, though the difference is clinically negligible

What the best clinical evidence shows about B12 injections and weight loss For people without a documented deficiency, the best human clinical data do not support B12 injections as a reliable method for weight loss

2022 (Scientific Reports): Combined NNMT inhibition + reduced calorie diet established a distinct microbiome in DIO mice additional mechanism but still mouse-only data