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1ah (vehicle (isotonic saline), n = 10 mice, 100 nmol kg 1 MK-801 n = 10 mice, 100 nmol kg 1 GLP-1 n = 10 mice, 100 nmol kg 1 GLP-1MK-801 n = 10 mice)

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But it offers significant advantages: lower cost, access to dose customization, and the ability to use compounded medications that are not available in pre-filled pen format

The therapeutic effects of GLP-1 RAslowering blood glucose and promoting weight lossare driven by interactions with G protein-coupled receptors (GPCRs) located in the pancreas, central nervous system (CNS), and peripheral tisses (Figure 1)(Zheng et al., 2024)