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Research indicates that high levels of Vitamin C can accelerate the degradation of histamine and inhibit its release from mast cells, providing immediate support for reducing the overall histamine burden

While most AMD cases (90%) begin as the less aggressive dry type, around 10% progress to the vision-threatening wet form

however, senescent cells infamously secrete high levels of pro-inflammatory cytokines, chemokines, and extracellular matrix-degrading proteins that negatively impact the extracellular environment and induce spread of senescence to non-senescent cells (29-32)

This was clearly demonstrated using Vav1-GPX4 fl/fl mice with a specific deletion of GPX4 in the hematopoietic system