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Nonetheless, to date the only FDA- and EMA-approved NRF2 activator for the treatment of relapsing-remitting MS and psoriasis is DMF, and its therapeutic potential in ALS patients in terms of efficacy, safety and tolerability, is now being evaluated in a phase-II clinical trial [313]

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Chronic cerebral hypoperfusion-induced impairment of a clearance requires HB-EGF-dependent sequential activation of HIF1 and MMP9

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The glucagon receptor is the key addition that drives retatrutides superior energy expenditure

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