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The authors analyzed data from a 104weeks cardiovascular outcomes trial in T2DM patients with hemoglobin A1c (HbA1c) 7% (semaglutide 0.5 or 1.0 mg/week) and a 52weeks weight management trial in obese patients without T2DM (semaglutide 0.050.4 mg/day)
GLP-1 receptor activation throughout the intestinal tract can completely halt peristalsis (the wave-like muscle contractions that move food through the digestive system), creating a medical emergency requiring immediate hospitalization
The inclusion of additional treatment comparators, such as SGLT2is, and clinical parameters including HbA1c, would also be of interest
If you are particularly sensitive to GLP-1 receptor activation, you might notice very subtle fullness after meals
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