When comparing KID, KIR, and a control the KIRA bioassay found that bioactive IGF1 levels all reached a similar magnitude without any significant differences between the three groups
This regimen (shown as a 50:50 dosage ratio) is more difficult to adjust because NPH has both a 2 hour delay, limited duration of action, and a time course that gives it prandial-like properties that can result in different levels of insulin stacking when another prandial insulin is given concomitantly (see Figure 14)
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