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Heavy metal poisoning may occur as a result of industrial exposure, air or water pollution, foods, medicines, improperly coated food containers, or the ingestion of lead-based paints. ~Rarediseases.org 5 Mental Health and Physical Health Symptoms of Mercury Toxicity Studies have revealed a direct link between toxic exposures and accumulations in the human body

Blood vessels in AD exhibit structural irregularities, such as twisting and varying diameters, and may develop cerebral amyloid angiopathy (CAA), significantly contributing to BBB disruption, diminished CBF, and cognitive deficits [19, 94, 184,185,186]

This modification reduces renal clearance, theoretically allowing lower daily doses to maintain sustained serum levels