Composed of glutamate, cysteine, and glycine, this endogenous thiol compound is examined in preclinical models addressing redox homeostasis, oxidative stress, and detoxification chemistry
Firstly, resveratrol decreases the expression of genes that are responsible for encoding the drug-metabolizing enzymes and drug transporters like ABC efflux transporters and proteins like MRP1/ABCC1 that contribute to the elimination of cancer drugs and chemoresistance [220, 221]
Thermodynamic analyses using ESI-MS revealed that cellular copper transport follows a gradient of increasing binding affinity, with Cu + binding to GSH ( K d~10 13 M) at lower affinity than to dedicated copper chaperones such as antioxidant 1 copper chaperone (ATOX1), copper chaperone for superoxide dismutase (CCS), or cytochrome oxidase copper chaperone COX17 (COX17) 197
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