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From the National Prescription Registry, we obtained the Defined Daily Doses (DDD) variable, which is based on the assumed average maintenance dose per day for a drug used for its main indication in adults, according to the World Health Organization Collaborating Centre for Drug Statistics Methodology (35)

In particular, when examining weight change when orlistat (Xenical, Cheplapharm) or liraglutide was injected in adults without diabetes who had a body mass index of 30 to 40 kg/m 2 , the weight loss effect was greater when liraglutide was used, especially when a high dose was used [10]

The proportional hazards assumption was evaluated using scaled Schoenfeld residuals

Study screening and selection procedure is summarized in Fig