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Relations between chemical structure and biological activity in peptides

Reduced FBXW7 expression raises substrate content, which in turn raises the activity of important lipid metabolism enzymes and causes abnormal lipid buildup in RTECs

deuteriujm bonds are stronger than hydrogen bonds, resulting in a slower rate of metabolism, (slower clearance), and longer half life, which reduces the dosing rate from 3 times a day to 2 times a day (Schneider et al, 2021)

( a ) Cells with shTMLHE were incubated with 13 C 2 -acetylcarnitine, and M + 2 acetyl-CoA was assessed (n = 8 technical replicates representative from 2 independent experiments)