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4.3 Comparative safety profiles of biomaterial and systemic therapeutic approaches Biomaterial delivery platforms can markedly reduce the off-target toxicities of systemic immunotherapies by concentrating antigen or immunomodulatory cargo in tolerogenic tissues or the diseased microenvironment, enabling lower total doses, controlled release, and biomimetic presentation that better recapitulates apoptotic-cell-driven tolerance (206, 207)

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A providers comfort level with these medications can significantly impact your treatment experience