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10.32474/sjo.2021.06.000232 52 HoskinD

The engineered fusion proteins became 168 amino acids in length, encoded by 504 nucleotides, including a native or modified GLP-1 (amino acids 130), a rigid helical linker (amino acids 3145) as EAAAKEAAAKEAAAK, and amino acids 46168 that belonged to HSA-binding DARPin

The study established that four hour intravenous infusions of GLP-1 (7-36) completely normalised blood glucose levels of patients with type 2 diabetes admitted to hospital for insulin therapy (Nauck, Klein, rskov)