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Nevertheless, these studies appear encouraging and more trials are underway. Although pain reduction remains important in OA, the big question and one representing a massive unmet need is whether the drugs can actually modify OA disease course

In published radioligand competition assays, tirzepatide binds the human GIP receptor with an affinity comparable to native GIP itself (Ki in the low picomolar range), while its affinity for the human GLP-1 receptor is approximately five-fold lower than that of native GLP-1

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Perhaps most intriguing is the drugs ability to go beyond physical health, providing relief and healing from historically complex mental health issues that can be difficultif not seemingly impossibleto treat with existing medications