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10.1016/j.cell.2016.07.043 Cell 67 HammondT

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However, under cellular conditions, the concentration (110 mM) of GSH is several folds higher than of hydroperoxides (10100 M), and thus, the velocity ( V max ) of the detoxification of hydroperoxides by seleno-GPxs is practically independent of the concentration of GSH [8, 17, 18]

Consequently, evidence supporting essentiality is assembled on the AOP page, rather than on the independent KE pages that are meant to stand-alone as modular units without reference to other KEs in the sequence