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Semaglutide is a selective GLP-1R agonist

Dual functional nanoparticles efficiently across the bloodbrain barrier to combat glioblastoma via simultaneously inhibit the PI3K pathway and NKG2A axis

Indeed, RYGB, which causes marked gastrointestinal distension due to how it forces food passage through the reconfigured gastrointestinal tract, leads to the same central pattern of neuronal activation as activating GLP-1R-expressing and OXR-expressing vagal afferents in mice [31, 36, 37], while vagotomy partially prevents the appetite suppression and weight loss caused by RYGB in rats [38]

April Le (Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section, National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism) and Mr