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LPS, lipopolysaccharide

Moreover, CARN was documented to upturn the genetic expression of peroxisome proliferator-activated receptor- coactivator 1-, a well-established crucial regulator of fatty acid oxidation and the Nrf2 gene, and a famous mitochondrial protector via boosting antioxidant levels and controlling mitophagy [20]

Additionally, ACEIs and ARBs directly counteract the toxic uremic effects of TMAO, which normally downregulates the expression of megalin, a crucial protein in renal albumin handling

Transporting long-chain fatty acids into the mitochondriayour cells' powerhousewhere the fats are oxidized to produce energy