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The low placental transfer could be caused by the release of Dipeptidyl peptidase IV positive syncytiotrophoblast-derived extracellular vesicles released by the human placenta which degrade GLP-1 in uterine blood (63), as well as to the high molecular weight of GLP-1 agonists (4 73 kDa)

Novo Nordisk claims that Ozempic helps your pancreas produce insulin so blood sugar levels lower

A closer look at the data from people without type 2 diabetes also showed that, compared to people taking a placebo, CagriSema users achieved bigger drops in their blood pressure and reported greater improvements in their quality of life over a 15-month period

While earlier work focused on direct action on pancreatic beta cells, more recent work has described additional neural actions including a satiety effect