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However, whereas the majority of hepatotoxic compounds cause centrilobular injury, some xenobiotics, such as allyl formage, elemental phosphorus, and allyl alcohol, preferentially damage periportal hepatocytes, presumably as a result of rapid first-pass uptake by these upstream hepatocytes

[10] Researchers have employed gene modification techniques to increase MC1R expression, which may alleviate experimentally induced liver cell fibrosis and possibly reduce the elevated expression of genes associated with fibrogenesis and inflammation

DEPTOR-Related mTOR Suppression Is Involved in Metformins Anti-Cancer Action in Human Liver Cancer Cells

Here is a study about the benefits of IGF-1 by PubMed Central (PMC) Click here