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Some of the serious side effects of Vitamin B12 include serous allergic reaction, narrowing or blocking of blood vessels, thrombocytosis (a disorder where your body produces too many platelets), low potassium levels in body, pulmonary edema (a condition where there is excess fluid in the lungs) and congestive heart failure

These antioxidants are vital for cellular health and protect the cell against oxygen radicals and mitochondrial oxidative stress

J Controlled Release (2006) 114:114

It can be rough on the digestive system, for example, capable of causing nausea, bloating, diarrhea, or constipation, and there havent been many studies on its long-term safety.47 So, a berberine supplement thats been through extensive third-party testing will be safer than most, as would one that was manufactured in an FDA-registered facility compliant with Good Manufacturing Practices (GMP)