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Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse

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Tuning the melatonin-responsive transcriptional switch Given that several pathways have been implicated in melatonin signaling 39,40 , we assessed whether MTNR1A activation by melatonin could induce transcription from a range of reporter promoters responsive to calcium signaling (NFAT), mitogen-activated protein kinase (MAPK/ERK), JAK/STAT, NF-B, TGF-/Smad and AhR

b Composite kidney outcome was comprised of development of macroalbuminuria, doubling of serum creatinine or an eGFR of 40 mL/min/1.73 m 2 , kidney replacement therapy, or death due to kidney disease