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In these studies, guinea pigs and BALB/c mice with allergic airway disease induced by ovalbumin sensitization had significantly lower total lung thiol content, with up to 40% lower GSH concentrations and threefold higher concentrations of GSSG in the lung tissue homogenate (172, 177)

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Through this comprehensive integration, we critically evaluated current strategies, identified emergent design paradigms, and categorized the most pressing translational challenges, offering a refined understanding essential for accelerating the clinical development of brain-targeted nano-phytochemicals

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