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ROS accumulation leads to the corresponding activation of the Keap1/Nrf2 pathway, and Nrf2 transcribes various antioxidant enzymes, including superoxide dismutase (SOD), heme oxygenase-1 (HO-1), and GSH

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According to the study, UA had a direct proinflammatory effect on human macrophages manifested by increased macrophage phagocytic activity, the production of TNF-alpha and toll-like receptor 4 (TLR4), and downregulated the urate anion transporter 1 expression. [ Uric acid is believed to contribute to the antioxidant potential in plasma but within the cell it is rather pro-oxidant