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In cancer patients, malnutrition is a prevalent issue that affects 20% to 80% of patients with this disease ( Consequently, it is best to concentrate nutritional approaches to treatment on recognizing the variables and symptoms related to these solid malignancies ( Regarding animals, inappetence is one of the primary clinical indicators that most veterinary oncologists (98%) cite as being important for classifying canine lymphoma patients as being in substage b, which is linked to a worse clinical prognosis (the median decrease in appetite required to classify the patient as substage b in this survey was approximately 40%) ( The hypothalamus is the main organ responsible for controlling hunger for mammals ( Figure 1 )