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Vitamin D levels should be checked periodically to avoid excess, while B12 has a wide safety margin.

Efficacy and safety of cagrilintide alone and in combination with semaglutide in patients with type 2 diabetes and obesity

[DOI] [PMC free article] [PubMed] [Google Scholar] 44.Elks J

What we do NOT know The gaps here are large enough that unknown long-term safety should itself be treated as a risk, not a green light: No long-term human safety data