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Late-Stage Treatment (after 48 hours or for established deformities): Incision and Drainage: If the hematoma has begun to solidify, a small incision may be necessary to remove the blood clot

Full effects within 34 weeks

(2015) 8:e14814

Pathological expansion and dysfunction of EAT promote AF through paracrine and vasocrine secretion of pro-inflammatory and pro-fibrotic cytokines, release of extracellular vesicles carrying arrhythmogenic cargo, direct infiltration, and modulation of local electrophysiology and autonomic signaling, thereby creating a substrate for atrial cardiomyopathy, fibrosis, electrical remodeling, and AF initiation/persistence