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Further, the extraordinary affinity of HGF for Dihexa (Kd=2.2 x 10 "13 M) suggests that normally non- biologically active levels of HGF become physiologically relevant in the presence of a high affinity mimetic

Such variability creates significant challenges for reproducibility particularly as few studies systematically evaluate how source material variability affects CQD composition and performance

Biotransformation (Hepatic Metabolism) of Drugs Metabolism is necessary for removal of lipophilic drugs from the body (Figure 4-13)

Reported effects include suppression of pro-inflammatory signals such as IL-6 and TNF-alpha as well as modulation of antioxidant enzymes (Dou et al., 2020)