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The Molecular Targets Driving the Revolution Modern incretin-based therapies harness three key hormone receptors that work together to regulate glucose metabolism, appetite, and energy balance: GLP-1R (Glucagon-Like Peptide-1 Receptor) Activated by drugs such as Semaglutide , this receptor stimulates insulin secretion, slows gastric emptying, and promotes satiety, helping reduce food intake and improve blood glucose control

However, both (Pro 3 )GIP and the GLP-1 receptor antagonist exendin(939)amide inhibited GIP-stimulated cAMP production in a concentration-dependent manner, by up to 70% and 73%, respectively