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Oral semaglutide was superior to placebo and other antihyperglycemic drugs, such as iDPP4 (sitagliptin), iSGLT2 (empagliflozin) or other arGLP-1 (liraglutide) in reducing HbA1c or weight.116 Oral semaglutide was well tolerated, with a safety profile similar to that of other arGLP-1 s

Because GLP-1s improve insulin sensitivity and regulate blood sugar levels, they may be prescribed off-label to treat symptoms of PCOS/PMOS, sometimes along with a diabetes medication called metformin

Certain genetic variants increase obesity risk FTO ) gene exhibit increased appetite, increased energy intake, and a preference for energy-dense foods [2,3]

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